Carcinogenic, Mutagenic or toxic to Reproduction (CMR), meeting the criteria for classification in category 1 or 2 in accordance with Directive 67/548/EEC or in category 1a or 1b in accordance with EC No 1272/2008This directive was recently replaced by the new EU regulation (EC) No 1272/2008.Ģ. SVHC are defined in Article 57 of Regulation (EC) No 1907/2006 (“the REACH Regulation”) and include substances which are:ġ. SVHC is a substance (identified by the European Chemicals Agency) that may have serious and often irreversible effects on human health and the environment.